Figure 2
From: Efficient reengineering of meso-scale topologies for functional networks in biomedical applications
Scheme of upstream/downstream inhibition. (a) Inhibitor acting on a signalling pathway upstream and downstream of a ‘merger’ node (black circle). If the ‘merger’ node has nonlinear characteristics, the inhibition can affect the entire response of the stimulation. (b) Inhibitor acting downstream of the ‘merger’ node only. Then the strength of the ‘joint’ stimulation signal is affected without change of the respective rate of the phosphorylation induced by the combined stimulation.