Figure 3
From: Efficient reengineering of meso-scale topologies for functional networks in biomedical applications
Effects of inhibition on induced phosphorylation. (a) Phosphorylation of a protein, stimulated by stimuli 1-3 and combinations without inhibition (x-axis) and with inhibition (y-axis). The sequence of the phosphorylations for all combinations of stimuli is different with and without inhibition indicating that the inhibition acts upstream of the joint node of the stimulation pathways. (b) Phosphorylation of a protein, stimulated by stimuli 1-3 and combinations without inhibition (x-axis) and with inhibition (y-axis). The sequence of the phosphorylations for all combinations of stimuli is the same with and without inhibition. This indicates that the inhibition acts downstream of the joint node of the stimulation pathways. The slope of the resulting line quantifies the impact of the inhibitor on the response of the protein with respect to stimulation.