Table 2 Value of the model parameters used in the numerical simulations (if not specified otherwise)
From: Mathematical assessment of drug build-up in the posterior eye following transscleral delivery
Parameter | Value | Unit | Description | Ref. |
|---|---|---|---|---|
\(t_{S}\) | 600 | μm | Sclera thickness | [13] |
\(t_{C}\) | 300 | μm | Choroid thickness | [13] |
\(t_{R}\) | 246 | μm | Retina thickness | [13] |
\(t_{V}\) | 15000 | μm | Vitreous thickness | [20] |
\((K/\mu)_{S}\) | 8.4⋅10−7 | cm2/s | Hydraulic conductivity in sclera | [8] |
\((K/\mu)_{C}\) | 2.35⋅10−11 | cm2/s | Hydraulic conductivity in choroid | [8] |
\((K/\mu)_{R}\) | 1.5⋅10−11 | cm2/s | Hydraulic conductivity in retina | [8] |
\((K/\mu)_{V}\) | 1.5−11 | cm2/s | Hydraulic conductivity in vitreous | [8] |
\(\mathcal{R}_{SC}\) | 10−7 | cm/s/mmHg | Hydraulic permeability at \(\Gamma_{SC}\) | |
\(\mathcal{R}_{CR}\) | 10−7 | cm/s/mmHg | Hydraulic permeability at \(\Gamma_{CR}\) | |
\(\mathcal{R}_{RV}\) | 10−7 | cm/s/mmHg | Hydraulic permeability at \(\Gamma_{RV}\) | [32] |
\(D_{S}\) | 4⋅10−7 | cm2/s | Drug diffusivity coefficient in sclera | [13] |
\(D_{C}\) | 1.6⋅10−7 | cm2/s | Drug diffusivity coefficient in choroid | [13] |
\(D_{R}\) | 1.17⋅10−7 | cm2/s | Drug diffusivity coefficient in retina | [13] |
\(D_{V}\) | 6 10−6 | cm2/s | Drug diffusivity coefficient in vitreous | [6] |
\(k_{S}\) | 3⋅10−4 | 1/s | Drug clearance/Decay coefficient in sclera | [13] |
\(k_{C}\) | 3⋅10−4 | 1/s | Drug clearance/Decay coefficient in choroid | [13] |
\(k_{Rt}\) | 3⋅10−4 | 1/s | Drug clearance/Decay coefficient in retinal tissue | [13] |
\(k_{Rb}\) | 3⋅10−4 | 1/s | Drug clearance/Decay coefficient in retinal blood | [13] |
\(k_{V}\) | 8⋅10−5 | 1/s | Drug clearance/Decay coefficient in vitreous | [11] |
\(\mathcal{L}_{SC}\) | 10−4 | cm/s | Permeability coefficient at \(\Gamma_{SC}\) | [21] |
\(\mathcal{L}_{CR}\) | 10−5 | cm/s | Permeability coefficient at \(\Gamma_{CR}\) | |
\(\mathcal{L}_{RV}\) | 10−5 | cm/s | Permeability coefficient at \(\Gamma_{RV}\) | |
\(\mathcal{P}_{CS}\) | 1 | adim | Partition coefficient at sclera/Choroid interface | [21] |
\(\mathcal{P}_{CR}\) | 1/1.33 | adim | Partition coefficient at choroid/Retina interface | [13] |
\(\mathcal{P}_{RV}\) | 1/10 | adim | Partition coefficient at retina/Vitreous interface | [21] |